Modernize your legacy mainframe systems

Modernize your legacy mainframe systems:
Migrate to cloud


Many organizations use legacy mainframe in their datacentres to run critical operations. This age-old system tuned and customized to the functional requirements, locked-in to vendors over the years, has been used extensively across business critical operations. Imperative to note that adequate resources to maintain and support these systems are currently scarce. The lack of an integrated testing environment limits flexibility, adds risk and increases test time. Over the forthcoming period, legacy technology is anticipated to encounter problems with maintenance, support, improvement, integration, and user experience. 

So how does your company overcome this impediment to growth? The answer is application, information and data migration. Migrating to the cloud presents tremendous scope for improving operational efficiency, reducing IT costs, enhancing performance and taking it to the next level. Modern technology solutions will introduce automation to manual process which are prone to errors. With enhanced reporting, featured UI and rules engine, business can manage data more efficiently and make changes in real time.

The objective is to sunset the legacy system with minimal disruption to the business and transition towards a more robust and scalable information technology platform. This holds immense potential in supporting current as well future business fleets with a cost effective and collaborative approach. Additionally, creating a common technology platform for operational applications can help businesses minimize data redundancy, decrease cost of building, and integrate and maintain new and existing applications.

Mitigating key roadblocks with sophisticated solutions

While cloud migration holds significant potential and offers an array of benefits, some of the challenges include:
  • Rewriting application architecture for the cloud
  • Complexity of the Integration of data, systems and processes
  • Compliance and security
  • Dealing with hybrid networking setups
  • Investing in people and tools needed to migrate successfully
  • Training users on the new systems
Solutions and Key Guiding principles –
  • Created reference architecture for the legacy application to migrate to a cloud native architecture on AWS
  • Compliance & Security, Hybrid connectivity – AWS Accounts/VPCs, including TGW, Direct Connect Gateway, multi region peering, Landing Zones, VPCs AZs Subnets, Security Groups, IAM role.
  • Data Security – Encrypted at Rest (AWS KMS), Encrypted at transit (SSL/TLS)
  • Real Time Transactions and Streaming, Messaging Integrations– SNS, SQS, MSK, Kinesis
  • Adapters – On-Prem to cloud protocol bridge
  • Use Serverless components/services as much as possible – Lambda, StepFunctions for workflow
  • AWS API Gateway – Lambda functions are invoked through API Gateway
  • Computation – Application container in EKS
  • ALB – EKS pods are invoked using ALB
  • AWS Secret Manager – Store credentials securely
  • Database – DynamoDB
  • Historical Data – S3
  • Disaster Recovery – Active/Active
  • Automated Deployment – CodePipeline, other CICD tools Monitoring and Observability – Cloudwatch, Datadog integration

From Bench to Breakthrough: Revolutionizing Drug Research with AI-Powered Integrated Assay Analysis

From Bench to Breakthrough:
Revolutionizing Drug Research with AI-Powered Integrated Assay Analysis


From Bench to Breakthrough:

Revolutionizing Drug Research with AI-Powered Integrated Assay Analysis 

In the dynamic landscape of life sciences research, the acceleration of discoveries and breakthroughs is of paramount importance. Today, integrated assay analysis, powered by cutting-edge AI solutions, represents a pivotal leap in scientific exploration, revolutionizing the pace, depth, and efficacy of research endeavors across diverse disciplines.

The challenge: Non-integrated lab management systems and manual bioassay analysis hamper drug discovery

Drug discovery and biopharmaceutical manufacturing rely on bioassays extensively. However, the lack of integration between assay analysis and lab management software is a major hindrance to research. Labs using non-integrated systems rely on manual work for assay-related analysis, which not only requires significant effort but also elevates the risk of human errors. Scientists, hence, require fully integrated software solutions that can improve assay analysis substantially through seamless integration with lab management software systems like laboratory information management systems (LIMS), scientific data management systems (SDMS), Sample Management Software, Electronic Lab Notebooks (ELN), etc.

The fix: Integrated assay analysis solutions powered by AI platform, tcgmcube

At TCG Digital, we offer a wide range of solutions enabling seamless integration with lab management software systems. With these solutions at your disposal, you can boost productivity and efficiency, whilst reducing the risk of errors. Our assay analysis solutions effectively cater to the different stages of drug development right from In vitro biology assays, In vitro ADME assays, pharmacokinetic (PK) studies, and In vivo pharmacology.

The integrated assay analysis solutions are built on the robust foundation of tcgmcube, an end-to-end AI platform that powers data analytics with comprehensive statistical and mathematical models, offering a transformative approach to assay analysis. Some of the solutions we offer include but are not limited to –
PK Modeling – Calibration Curve Generation
  • Generates calibration curve using known concentrations of the analyte being assayed
  • Assortment of curve-fitting models and residual weights
  • Application of sample acceptance and plate acceptance criteria
Anti-Drug Antibody (ADA) Assay Analysis (Immunogenicity)
  • Computes Immunogenicity cut-points (parametric & non-parametric analysis)
  • Covers steps for screening, confirmatory, titer, and neutralization
  • Applies cut points and rules at the sample/replicate/plate levels
Method Validation for ADA and PKA Assays
  • Covers accuracy, precision, sensitivity, specificity, selectivity, robustness, dilution linearity and integrity, drug-tolerance, assessment of Hook effect, and stability
  • Integrated solution and reporting
Meso Scale Discovery (MSD) Assays with Multiple Spots (multiplex)
  • Generates standards curve with run acceptance parameters
  • Assortment of curve-fitting models and residual weights
  • Application of SAC and PAC
  • Analysis for multiple spots
  • Matches a specific DNA sequence from a sample using sequence rule files to assess the genotype and metabolizer status
  • Maintains consolidated mapping rules for each gene family
Gene Expression
  • Uses qPCR, ELISA, or Western Blot assays
  • Flexibility to omit samples and select controls from housekeeping gene assays
  • Flags samples based on CV acceptance criteria
  • Integrated reporting
  • Used for the quantitative measurement of gene copy number or the presence of mutant genes.
  • Standard curve with log of quantity as x & Ct value as y
  • Application of specifications
Virus Neutralizing Assays
  • Analyzes inhibition of viral binding to the cell
  • Cell Control zone and Virus Control zone calculations
  • Inhibition % calculations
  • Flags based on % CV criteria
  • Results at sample and well level
Virus Neutralizing
Assays (RSV)
  • Analyzes inhibition of viral binding to the cell or inhibition of viral reverse transcription
  • Virus Control calculations
  • Individual plates titer table
  • Summary titer table
  • Results at plate, batch, sample, and well level
Key features of our assay analysis solutions include:
  • Seamless integration with laboratory data sources
  • Ability to read data directly from data sources and write back the analysis outcome into them for the analyst to take further action
  • Access to multiple curve fitting models, both linear and non-linear
  • Generation of run acceptance parameters and relevant reports
  • Support for defined user interactions for scenario creations
  • Method validation support
  • M10 reporting options

Creating future-ready labs: Fast-tracking research, bolstering drug discovery

Integrate seamlessly with diverse laboratory software like LIMS, SDMS, Sample Management Software, ELN, etc. with our integrated assay analysis solutions.

TCG Digital’s comprehensive assay analysis solutions library is tailored for future labs. You can benefit from their ability to simplify data management, improve overall operational efficiency, and minimize errors. Integrated assay analysis solutions also enable different user interactions, data modeling, and report generation across labs. Accelerate research and enhance data accuracy in bioassay analysis with our cutting-edge AI-powered solutions.

Significant benefits reaped by organizations using our integrated approach:
  • Upto 50%
    reduction in cost and time for analysis and validation for
    a leading bio-tech company
  • Upto 25%
    expected cost savings from manpower efficiency and reduced cost of
    rework for a leading bio-tech company
  • Upto 20%
    expected cost savings from manpower efficiency and reduced cost of
    rework for a big pharma
In conclusion, integrated assay analysis has emerged as critical for accelerating research, particularly in the area of drug discoveries. Leveraging tcgmcube’s AI-powered integrated assay analysis solutions stands as a beacon of progress in life sciences research. For all the scientists in the pursuit of expediting discoveries, unlocking novel insights, and propelling scientific advancements, the synergy between integrated assay analysis and TCG Digital’s comprehensive solutions library holds immense promise.Embark on a journey of transformation and innovation with our fast, accurate, and regulatory-compliant assay analysis solutions for unparalleled drug discovery.

To know more about integrated assay analysis, write to us at